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Results overview

Bishop et al — study overview

Resected NSCLC cases

102 resected NSCLCs were classified as SqCC or adenocarcinoma using traditional histologic features and immunohistochemical profiles and MiRview™ squamous

Preoperative biopsies/aspirates NSCLC cases

21 preoperative biopsies/aspirates that had been originally diagnosed as poorly differentiated NSCLCs
A qRT-PCR diagnostic assay measured hsa-miR-205 expression levels to classify the carcinomas as SqCC or adenocarcinoma based solely on expression levels
The sets of classifications were then compared

Case 87 from Bishop et al

This sample was diagnosed as a poorly differentiated NSCLC based on a preoperative fine-needle aspiration.

1. The unstained sample shows scattered discohesive and degenerating atypical cells in a background of blood

2. Using nuclear p63 immunolabeling, the sample suggests a SqCC

3. The subsequent lung resection shows an adenocarcinoma with clear-cut glandular differentiation

4. Using microRNA biomarkers, both the preoperative aspirate and resection samples were diagnostic of adenocarcinoma

Figure reprinted with permission from the American Association for Cancer Research. Figure 3 from Bishop JA, Benjamin H, Cholakh H, Chajat A, Clark DP, Westra WH. Accurate classification of non–small cell lung carcinoma using a novel microRNA-based approach. Clin Cancer Res. 2010;16(2):610-619.