miRview® mets² and miRview® mets  

Cutting-edge molecular diagnostics

The miRview mets assays utilize proprietary technologies developed by Rosetta Genomics for extraction and quantification of microRNAs. Based on the expression level of the extracted microRNAs, the tests utilize two classiferes to assign the tested sample with a predicted primary origin.

 

miRview® mets - This qRT-PCR based test measures the expression level of 48 microRNAs and can identify 25 primary origin of metastases.

 

NEW  - miRview® mets² - This is a second generation version of miRview® mets. This test uses custom-designed microarray technology and can identify 42 primary origins by measuring the expression level of 64 microRNAs 

 

 

Extensive experience and validation

miRview® mets² and miRview® mets are the products of more than three years of research analyzing hundreds of tumor samples. The tests have been developed using rigorous guidlines and validated using blinded samples. The tests are offered through Rosetta Genomics CLIA-certified, CAP accredited laboratory, and are available in the United States, Canada, Israel, Greece, Australia, and India.  

 

Performance Characteristics

miRview® mets - Performance of this assay was determined in an independent, blinded test. In the majority of cases, miRview®mets returned a single tissue prediction with 90% sensitivity and 99% specificity².

miRview® mets² -  Performance of this assay was determined in an independent, blinded test. In the -vast-majority of cases, miRview®mets returned a single tissue prediction with 90% sensitivity and 99% specificity. Overall sensitivity was 85%.

 

While many of the cancer tests currently available are largely qualitative and subjective, the measurement of microRNA expression levels in tissue samples offers a quantitative, objective diagnosis. Proprietary technologies enable microRNA profiling with high sensitivity and specificity (for miRview® mets, these values have been shown to be 90% and 99%, respectively)². In addition, microRNAs are stable markers in many body fluids and tissue samples, making them an ideal platform for molecular diagnostics.