miRview™ meso utilizes proprietary technology developed by Rosetta Genomics. This technology includes protocols for the extraction of microRNA from formalin-fixed paraffin-embedded (FFPE) tissue samples and quantification of the relative amounts of specific microRNAs using quantitative real-time polymerase chain reaction (qRT-PCR) technology to indicate the levels of mesothelioma- and non-mesothelioma―specific microRNA markers.

miRview™ meso is the product of two years of research with hundreds of tumor samples. In the first phase of development, more than 100 tumor samples (including mesothelioma and non-mesothelioma cancer samples) were studied by high-throughput molecular profiling¹. Molecular profiling using microRNA microarrays was used to identify the molecular markers for mesothelioma or other cancers¹. In the second phase, the microRNA markers were validated and a diagnostic assay defined using sensitive and specific proprietary qRT-PCR technology¹.
The performance of the miRview™ meso assay was determined in an independent, blinded test. The sensitivity and specificity of this assay have been shown to be 100% and 94%, respectively².

While many of the cancer tests currently available are largely qualitative and subjective, the measurement of microRNA expression levels in tissue samples offers a quantitative, objective diagnosis. Proprietary technologies enable microRNA profiling with high sensitivity and specificity (these values have been shown to be 100% and 94%, respectively)². In addition, microRNAs are stable markers in many body fluids and tissue samples, making them an ideal platform for molecular diagnostics.

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1. Rosenfeld N, Aharonov R, Meiri E, et al. MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol. 2008;26(4):462-469.
2. Data on file, Rosetta Genomics.